More recently, a number of human trials have been undertaken to establish the efficacy of MSM in musculoskeletal disorders. Jacob and Lawrence6 have conducted controlled studies using MSM in cases of arthritis. Jacob6 compared MSM to the over-thecounter, nonsteroidal anti-inflammatory drug, Motrin (Ibuprofen). Subjects in both groups reported the same degree of pain relief after one month of follow up.
For osteoarthritis: Up to 500 mg three times daily. The doses upto 3 grams twice daily are also reported in clinical trials.