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Taurine: Comparable activity to diclofenac in arthritis

  • Rats were allocated into five groups (n = 10). The normal and control groups received normal saline. The remaining three groups were treated with diclofenac (2 mg/kg), taurine (5 mg/kg) or taurine (50 mg/kg) respectively. Drugs were i.p. injected for 26 successive days starting from the onset of adjuvant induction. Arthritis was induced by s.c. injection of 0.4ml of Freund’s complete adjuvant (FCA) into the sub plantar region of the right hind paws of rats in all groups except the normal one. Paw volume was measured before and at different time intervals after adjuvant inoculation. After the last measurement, blood samples were collected and were used for estimation of serum levels of lipid peroxides, nitrite, total antioxidants, tumor necrosis factor-alpha and interleukin-1beta as well as lactate dehydrogenase activity. Histopathological examination of knee tissues of all rats was also performed.

  • Results: Injection of FCA induced marked arthritis manifested by paw edema during the 26-day experiment period. Treatment with diclofenac or taurine (50 mg/kg) markedly inhibited adjuvant initiated arthritis as well as its associated biochemical and histological changes. Taurine (5 mg/kg) did not affect FCA-induced paw edema but it attenuated some of the induced biochemical changes.

  • Conclusions: Taurine effects could be explained by inhibition of pro-inflammatory cytokines production as well as its antioxidant effects29.

  Dosage

  • Dosages between 500mg-2,000 mg have shown efficacy, although the upper limit for toxicity is placed at a much greater level and high doses are welltolerated30.

  • The upper limit for which one can be relatively assured no side effects will occur over a lifetime has been suggested to be 3,000 mg a day30. However, dosages up to 6,000 mg have been seen in cardiac patients trying to lower blood pressure31.