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Glucosamine + Msm: The Synergistic Combination

  • In a study of oral glucosamine and MSM in the Journal of Clinical Drug Investigation, researchers recruited 118 men and women with mild to moderate OA. For 12 weeks participants took 500 mg of glucosamine three times per day, 500 mg of MSM three times per day, combined these two treatments or took a placebo. Scientists measured participants at the start of the study and every two weeks and found that glucosamine and MSM separately and combined significantly reduced inflammation and pain compared to placebo. Those who took glucosamine and MSM together reported the greatest decrease in pain had the most rapid relief from inflammation, and  the quickest improvement in movement14.


  • The results showed that both MSM and glucosamine improved arthritis symptoms as compared to placebo and that the combination of MSM and glucosamine  was more effective than either one alone14.

  • Another randomized, double-blind trial compared MSM, glucosamine both or placebo for osteoarthritis of the knee15. Approximately 30 patients per group. Dose was 1,500 mg per day for 12 weeks. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15 meters walking time, the Lequesne index, and consumption of rescue medicine. There were statistically significant decreases in pain with glucosamine and with MSM respectively. The combination treatment resulted in a more significant decrease in the mean pain index than either treatment alone. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents15.